With Professor Colleen Aldous
Critical appraisal of multidrug therapy in the ambulatory
management of patients with COVID-19 and hypoxemia
Part II: Causal inference using the Bradford Hill criteria
We continue the critical appraisal of three published case series of 119 COVID-19 patients with hypoxemia, treated in the United States, Zimbabwe, and Nigeria with similar ivermectin-based multidrug treatments, to assess the available evidence supporting a causal relationship between treatment and reduction in hospitalizations and mortality. A narrative review was conducted to assess the Bradford Hill criteria for a causal association. We used a previously proposed refinement of the Bradford Hill criteria that reorganized them into three categories of direct, mechanistic, and
parallel evidence. The efficacy of the two most aggressive ivermectin-based
multidrug protocols is supported by the Bradford Hill criteria for temporality,
strength of association, biological gradient, biological plausibility, coherence, consistency, and analogy. The causal relation between the treatment of hypoxemic COVID-19 patients using these protocols and the reduction in hospitalizations and mortality is supported as an inference to the best explanation.
Critical appraisal of multidrug therapy in the ambulatory
management of patients with COVID-19 and hypoxemia
Part I. Evidence supporting the strength of association
On March 11, 2020, Coronavirus Disease 2019 (COVID-19), the disease caused by the Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2), was declared a pandemic by the World Health Organization (WHO) [1]. Worldwide, 768,187,096 confirmed cases of COVID-19 and 6,945,714 deaths have been reported to the WHO as of June 21 2023, amounting to an average Case Fatality Rate (CFR) of 0.9% [2]. During 2020, while several governments and public health agencies were focused on contagion control and in-hospital patient care, several medical doctors from all around the world innovated and discovered early outpatient multidrug treatments using several repurposed medications in combination [3–15]. In the United States, several independent efforts coalesced into the formulation of a sequenced multidrug protocol [10, Fig. 3] (hereafter, McCullough protocol), which is based on the pathophysiological understanding of COVID-19 as a triphasic illness with three overlapping phases: (1) viral proliferation; (2) hyperinflammatory cytokine storm (COVID-19 pneumonia); and (3) thrombosis. McCullough’s protocol proposed a combination antiviral therapy for treating the viral proliferation phase, immunomodulators for treating the cytokine storm, and antiplatelet agents and antithrombotics for handling the thrombotic stage, based on risk stratification and how the disease presents in each individual patient. Thus, the McCullough protocol is an algorithmic treatment using sequenced multiple drugs in combination and customized to the individual patient and their response to treatment; no single drug is necessary nor sufficient to achieve treatment efficacy towards reducing hospitalizations and deaths. A recently published update of the McCullough protocol [16, Fig. 3] introduced some adjustments including virucidal nasal washes and oral gargles [17–24]. A large case series of 869 high-risk patients [25, 26], who were treated using an early version of the McCullough protocol, has been compared against population-level and historical controls [27], showing the existence of efficacy with respect to the reduction of mortality and hospitalizations, which is also resilient with respect to random selection bias, provided that patients are treated early enough within the first 3 to 5 days from the onset of illness. Indeed, an earlier study by Fazio et al.[28] showed that the ideal window of opportunity for initiating an effective early outpatient treatment of COVID-19 to prevent hospitalization is approximately within the first 3 days.
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The horse paste is a lot cheaper and works for me repeatedly against the common cold. I love it
In the Netherlands Dokters who cave patients Ivermectine get punished.In the Netherlands you can't get Ivermectine
https://youtu.be/_LF_k4hNxUc?si=kCnfwGFoxfjPJYVL
I lost 100s of dollars in convescated ivm. 😢
How about…Fenbendazole as well
Great interview! Thank you!
"…in a coordinated way around d the world".
In the same way, by the same "tools of ßáál" that spread the life story of LHO around the world & even New Zealand(Fletcher Proudy), hours after LHO didn't shoot anyone with a defective Manlicker-Carcano.
How do I know?
Research, over half a century of deep, deep state research.
How deep?
Well, did you know Mr. Carcanos first name is Salvatore?
Manlicker?
Ferdinand Ritter von Manlicker!!I
Ivermectin is no more complex than yogurt;
Streptomyces avermitilis secrets 8 closely related virus killers to protect itself.
This is what Ivermectin is made from.
Way back in the previous century my uncle bought it in 50lb bags for his dairy cows.
Btw~✓you haven't lived until you had ice 🍦cream made with raw milk!
Hey Dr John can you time stamp these long videos. Great content BTW thx.
Strange things are happening in this world…
My wife has been dealing with severe health conditions, including autoimmune conditions. Polypharm is part of the root cause and we are working to get her off many meds. Big issue is Asthma where she is performing daily nebulizer meds with limited success. I pushed the Doctor to have Spike Protein antibody test. Results showed level of 800 U/ml with normal level less than 13 U/ml per results provided. She has not had a recent infection, Should we be concerned? Would an Ivermectin treatment reduce the spike protein decoupling from red cells and improve her breathing?
Can someone tell me where I can buy genuine 12mg IVM in UK? And yes I stayed to the end? While I must add googling where to buy 12mg IVM tablets. I'm very cynical about possible counterfeit IVM. So in a quandary. I'm in good health however that can change in a heartbeat. My brother-in-law has stage 2 tongue cancer and is facing a seven hour operation in three weeks time.
I tell family and friends to take vitamin 8kiu's D3 daily, and some look at me like I'm a witch doctor so IVM would scare them witless? Thankfully most are on vitamin D3.
Please send this to RFK JR, the new US SEC of Health and Human Services. He will make sure it gets read 📚 ❤🎉
The problem is that those given control of decisions were not competent medical leaders they were Evil control fascists!!!
It infuriates me that Fauchi is not in prison for murder or at least an Insane asylum to protect the world from his
Ever being allowed to influence medical decisions again 🙄 🙃 😢!!! Greed is killing us 😫
🌿🌺🕊 I watched “all the way through” Dr. Campbell…Thank you both for life saving information❣️Luv from America 🙏🕊
Ivermectin has years of worldwide anecdotal and correlation studies. The NIH has several clinical studies demonstrating its efficacy. It's all online. I make my meds with enteric capsules into which I put a pencil eraser amount of Ivermectin which I buy from a nearby animal supply store. I take one capsule every other day. NIH studies show an Ivermectin half life of 20-24 hours. Ivermectin is also anti metastatic. I also take daily one Thorne Quercetin phytosome anti metastatic capsule also for backup. This NOT a recommendation. This is what I worked out after months studying dozens of natural international remedies on NIH website.
Lab leak or what? A very organised international plan by very sinister people?
Ivermectin saved my life. Went from breathing difficulty to clear breathing in two days. If I would have listened to my doctor I would be dead.
Initially when ivermectin got the world’s attention, I believe many Africans said that they’ve used ivermectin for ages and it had the nickname – the Sunday.
The pill which is really cheap is sold over the counter.
When I heard you and others starting to talk about ivermectin re cancer, I started looking around to see if I could source it.
All I found was veterinary and it was really expensive… I think it’s $10/tablet. Has big pharma buried it to ensure we can never use this cheap generic?
Thank you
I watch every one of your videos through to the end!!! THANK YOU!!
How do you get the pills? Prescription?
It's almost as though those studies were designed to have negative result rather than to be helpful in any way…
Can anyone tell me where can I get this if I live in Canada?
My dose was 21mg Ivermectin and I was 125 lbs. 0 side effects. My lungs were already damaged from severe ARDS from 2014. I got Delta in 2021 and did great. Didn't even need to use my oxygen. Also never got the jab.
remdesivir was patented by anthony fauci / remdesivir was patented by Anthony Fauci / remdesivir was patented by Anthony Fauci / rthen he sold the patent so his name would not be on it
Thank you both for dedicating so much time and effort to serve others- to bring out the truth, and hope :)
The more I hear about ivermectin the more I think I need to have some on hand.
Why is ivermectin still forbidden in the EU…is should be free available for everyone
And to think we wouldn't know any of this if it wasn't for independent voices getting out there through the internet. Imagine if they unleashed the Covid19 in the 1980's. What fun the elites would have had. We would all be on our 30th booster and getting sicker and sicker with all our young dying.
My husband has lip cancer i wonder if ivrmctn wud work on that?
Really appreciate your interesting discussions and observations.
The problem with outsourcing thinking to models, and limiting it to rules and frameworks, is definitely letting down scientific research.
It would appear to corroborate Iain McGilchrist’s observations that we are living in a world where the master, the right hemisphere of the brain, has been usurped by the emissary, the left hemisphere, which mistakes the map for the territory and knows that it is always right, despite all the evidence to the contrary.
Unfortunately, it is ordinary people who ultimately pay the price when science has devolved into scientism.
I enjoyed the interview with colleen and the importance of ivermectin. i think that they knew what they did and did it on purpose.
I think the toacco companies knew that smoking caused cancer!!
Big pharma are only interested in profits, not human life, and as soon as the people in the world realise this, i believe one day big pharma will be in bid trouble.
One of the best videos I have ever heard of the research regarding ivermectin… Thank you so much and God bless you
What countries sell ivermectin over the counter?
My wife she has Gliobastoma level 4 and I am giving her 24mg of Ivermectin a day… her normal weight is around 40Kg and 1.55 mts tall. I believe Ivermectin has help her with the treatment of quimio and radio… she is not getting worst… she is not losing weight either and in about 2 month she will have her brain scan again and then is when we will know if Ivermectin has done something but let me tell you all, she is going to the gym almost everyday… even if she doesn’t have the same energy, she walks the dogs, wants to go outdoors and all that. Her skin looks pinkish sort of healthy… and her headache is gone… I really think is working. I have to bring the dosis to around 40mg a day for about 3 month… but I am monitoring her everyday. If I give her the Ivermectin an hour prior breakfast she doesn’t have any symptoms at all, only when she take her dosis with in minutes of having breakfast is when she feels the need to go to the bathroom… but no fever, no nausea, no headache, nothing. She had surgery 4 month ago.
Where can we get Ivermectin?
People are using low dose horse ivermectin with good results .
Thank you John & Professor Aldous. Well done.
They wanted to hide their trial data pushing for 75 years with the FDA backing… That should be enough for prosecution for any justice ⚖️
Look at that DATA!
And they want to say no harm has or is being caused?
Whiskey tango foxtrot!!!
!…FABULOUS INTERVIEW — THANK YOU…!
I enjoyed
Has anyone used Ivermectin cream for basil carcinoma? I want to avoid Moe's surgery on my forehead. Appreciate any advice❤
Why are people still dying of COVID 19?
Thank you again for another delightful discussion and break down to the truth
Welcome indeed and welcome back Professor.
Another excellent interview. Thank you for bringing these studies to attention. I listen to most of your videos all the way through Dr Campbell, they are always very informative. Only sometimes i stop because it's a snippet of a longer video that I've already seen, so if others are like me maybe the percentage is actually higher 🙂
Fabulous discussion. Thanks greatly!! From a retired microbiologist.
Thankyou so much……Brilliantly researched, …….A grateful heart , knowing the dedication and authentic commitment to the truth and those endless hours of working away at the remedy. Keeping always in the forefront of your mindset…..the Hippocratic Oath….doing good and do NO harm…..etc!
Love your work!!!! Take care!!!! From Australia 🇦🇺