Time-lapse imaging of bacteria called M. smegmatis growth inside a tiny fluid device. These bacteria had a glowing green (🟢) protein (MalI-mNeonGreen) inside them. Then, a very small amount of virus (called Fionnbharth-MalO phage) was added which had been stained with a red dye (SYTOX Orange).
This video shows one virus attach to a bacterium cell (shown as a red dot). Soon after, a green spot appeared nearby. This suggests the virus injected its DNA into the cell. As the infection went on, the single green dot turned into many green spots. These spread out inside the cell and formed groups where the virus DNA was making copies of itself. In the end, the cell burst open (lysis), releasing new viruses to infect other cells.
Source: Dulberger et al. 2023 Nature Microbiol.
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