Subscribe to our channel:
Check out the paper:
Related episodes:
The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21:
A recent paper demonstrating that injecting older mice with an anti-IL-11 drug extended their median lifespan made a splash in the geroscience community this summer. IL-11 is a proinflammatory cytokine that plays a role in regulating various biological processes, including hematopoiesis (the production of blood cells), bone health and remodeling, and tissue repair. Meanwhile, cytokines act as messengers between cells, helping to regulate immune responses, inflammation, and the production of blood cells. In excess or when dysregulated, cytokines can contribute to chronic inflammation and autoimmune diseases.
In this episode, Matt discusses the role IL-11 plays in the body, the ERK, AMPK, and mTOR pathways, genetic and pharmacological models of IL-11 reduction, and more. He goes over the paper’s claims and provides his take on whether this finding is a game-changer in the longevity field as well as on what further questions he’d like to see answered in follow-up studies.
0:00 Introduction
11:17 Starting the deep dive
13:21 Looking at the abstract
26:41 The proposed mechanistic model + what we know about ERK
36:28 Examining the data + comparing the results with other findings
55:45 Takeaways
Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.
More places to find us:
Twitter:
Twitter:
Twitter:
Linkedin:
Hi, I’m Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.
On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don’t know. I hope you’ll find these episodes helpful!
source
Jackson Mark Robinson Larry Young Carol
Matt, this is incredible how clear you explained the various dependencies and pathways! Well done and thank you sharing this with us. Great education
Garcia Sandra Allen Donald Williams Sharon
Great explanations of the technical aspects of this research.
I like that IL-11 inhibition has shown improved glucose tolerance.
When I take 6mg/wk of Rapamycin, it definitely increases my blood glucose for a couple of days (per CGM).
I am also becoming intrigued with Peptides, and would really like to hear Matt's opinion on the current favorites.
Wow! Explaining this study, one of Matt's best podcasts!
I am sure there is some natural product or safe drug out there that has some inhibitory effect on IL11 receptor. If I find it, I will take it if there are no obvious side effects. Half the stuff I eat as food has side effects, so it is a risk worth taking
I know that clicking like helps a video. I try to click like when I actually laugh or when something important is said. "If people would just figure this shit out" was the moment for this video.
Could you guys do a summary of evidence for longevity video on tadalafil please
thing is, if there's a study in animals showing a supplement can block IL-11, it's fair to state that.
Animal evidence is better than no evidence. I agree on not making statements about said data being extrapolated to humans though
Please put the following into layman's terms: "Candidate nutrients discussed in this review primarily include lutein/zeaxanthin and phytochemicals like allicin, osthole, β-elemene, quercetin, curcumin, and rosmarinic acid, which primarily mitigate p-ERK/SNAI1 signaling axes exacerbating IL-11 production."
ChatGPT said: Here's a simplified version: "The nutrients being discussed include substances like lutein, zeaxanthin, and plant compounds such as allicin (found in garlic), osthole, β-elemene, quercetin, curcumin (from turmeric), and rosmarinic acid. These nutrients help reduce a specific cellular process that leads to the production of a protein called IL-11, which is linked to inflammation." It’s basically saying that these nutrients can help calm down a process in the body that might otherwise worsen inflammation.
Chronic Kidney Disease Diets for Kidney Failure Prevention: Insights from the IL-11 Paradigm- "Candidate nutrients discussed in this review primarily include lutein/zeaxanthin and phytochemicals like allicin, osthole, β-elemene, quercetin, curcumin, and rosmarinic acid, which primarily mitigate p-ERK/SNAI1 signaling axes exacerbating IL-11 production."
Wish you'd focus more on anti-aging peptides, specifically Klotho and Follistatin.
Excellent talk Matt could you please advise where you got that beautiful if intimidating Network diagram. I'd like to use it in an upcoming talk on the biology of Aging. I've searched for it and I can't find it. Could you post its location? Many thanks, Dr Doug Watt
Do you know how long it might take for available IL-11 therapy to humans?
Hi Dr. Kaeberlein,
Could you clarify what you mean by looking outside the hallmarks of aging? Are you referring only to finding new interventions beyond those like calorie restriction? I understand you’re involved with the Million Molecule Challenge. What other approaches or areas do you see as promising?
If you theoretically reduce the calorie intake for a person by 65%? What happened then? Doesn't that show that none of these mouse experiments are really very transferable to humans
Melatonin has shown potential in reducing interleukin-11 (IL-11) in certain cancer studies
it's great to hear such an analysis of a paper
When I was a grad student, I stole two Long-Evans rats in the lab to keep them as pets. I didn't feed them very much, partly because I had barely anything to eat myself and partly as I was treating them as an experiment on calorie restriction and longevity. The rats lived to 3.5 and 4.5 years, much longer than normal life span of a rat. The older one essentially died of depression (refused to eat and became malnutrished) after it lost sight to an eye infection, so perhaps could live even longer. I'm in my 40s right now and people typically guess I'm 10-15 years younger. I practice calorie restriction too.
EDIT: Calorie restriction applied in adulthood extends lifespan in mice: Weindruch and Walford, Science, 1982.
Interesting stuff 🤔🤔