Matt Kaeberlein reflects on “David Sinclair’s Longevity Lie” | 62 – Longevity Reacts #5
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In this episode, Matt and Nick react to investigative journalist and author Scott Carney’s video describing what he calls “David Sinclair’s longevity lie” in the context of David’s longevity-focused entrepreneurial ventures. Matt shares his professional history with David, including his early interactions with David in Leonard Guarente’s lab at the Massachusetts Institute of Technology (MIT) and scientific differences that emerged after Matt and colleagues were unable to reproduce a key result from David’s work pertaining to resveratrol. Their discussion touches on some of David’s scientific claims about age reversal, the role of institutions such as Harvard University in regulating scientific integrity, the potential for future interventions in healthspan and longevity, and the importance of separating personal feelings from scientific evaluation.
David, currently a professor in Harvard Medical School’s Department of Genetics at the Paul F. Glenn Center for Biology of Aging Research, is a prominent geroscience researcher whose lab focuses on age-related epigenetic change, cellular reprograming, longevity drug discovery, mitochondrial fitness, reproductive aging, neurodegenerative disease, and the human secretome. He has received awards including the National Institutes of Health Nathan Shock Award, the Merck Prize, and the Australian Medical Research Medal, and was elected to TIME’s 2014 “100 Most Influential People in the World” list. David conducted postdoctoral research at MIT and obtained a PhD in Molecular Genetics at the University of New South Wales.
0:00 Introduction
6:12 The video begins
7:21 Claims of immortality
8:26 The consequences of making unsubstantiated claims
10:23 A logical fallacy
15:04 Some clarifications about SIR2
17:23 TED Talks + getting information from credible sources
19:15 Setting the record straight on sirtuins and lifespan
22:19 Reproducible work from David’s lab
24:02 GlaxoSmithKline’s decision
25:42 Conflating the resveratrol story with sirtuin biology
26:10 A “buddy system” of reviewing papers
30:57 Andrew Huberman and Peter Attia + bashing the scientific enterprise
33:20 Show us the data
37:25 Why hasn’t Harvard taken action?
41:41 Not a totally fake space
44:34 Relationship with the FDA
50:04 Matt’s resignation from the Academy for Health & Lifespan Research
54:14 Immortality vs tackling the biology of aging
56:13 Closing thoughts
58:55 Looking at the comments
Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa
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Hi, I’m Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.
On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don’t know. I hope you’ll find these episodes helpful!
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