IL-11, Trametinib & Rapamycin = Impressive Lifespan Effects? We Take a Look. | 63 – LTW #10
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Check out paper #1 on IL-11 signaling:
Check out paper #2 on combination trametinib/rapamycin treatment:
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An introduction to the study of RAPAMYCIN:
In this episode, Matt discusses two recent mouse lifespan studies: one focused on inhibiting IL-11 signaling, and one focused on combined trametinib and rapamycin treatment. IL-11, or Interleukin-11, is a protein that plays an important role in modulating inflammation and healing, while trametinib is an FDA-approved drug that targets certain cancers, particularly melanoma. You can find extensive discussion of rapamycin in our R-Files series linked above. Matt explains the “900-day rule” for evaluating mouse lifespan studies such as these two, and provides his take on whether these results are game-changers for the geroscience field as well as whether we should consider these interventions for human use at this time.
0:00 Introduction
2:22 The 900-day rule
4:35 Applying the rule in practice: the IL-11 paper
7:48 Comparing the result to that of other lifespan experiments
10:55 Applying the rule in practice: trametinib/rapamycin combination treatment
15:47 Takeaways
Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa
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Hi, I’m Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.
On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don’t know. I hope you’ll find these episodes helpful!
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Matt is always talking about “wrap a mice in…” and poor grammar aside, I wish he would tell us what the mice are wrapped in.
This video is so important I watched it twice. And then shared it widely.
Dear Sir, I am 47 years old man, for 12 years I took prednisone and azathioprine because of autoimmune hepatitis. Now for fifteen years I have not taken them because I have achieved remission. My ALT and AST fluctuate between 20 and 30. I would like to take rapamycin for so-called "longevity". Have you had such a clinical case of autoimmune hepatitis and taking rapamycin for longevity?. I do not take any medication, except for vitamin D3. Can I aggravate the disease, or is it possible or regulate my immune system to decrease my ALT and AST below 20 ? Thank you very much in advance.
Best regards, Robert.
Trametinib 0.5mg is $3786.00 for 30 tabs
Talking about Rapamicin is just a tease since most of us cant get any…
Maybe a focus on nutrition might be helpful to reduce il-11.
My diet (whole food, no grains but wheat germ) reduces my cytokines in general. I've never checked for il-11. Maybe I should.
Siim Land in his most recent video is claiming glycine can extend lifespan in humans. Make out of that what you will.
I am curious to know how long the controls lived in the rapamycin experiment. You made it sounds as if the untreated mice lived longer (had to be 900 days plus).
If that's the case, this plus the benefits of rapamycin, might have made them live longer compared to to their mice plus rapamycin and trametinib?
Or am I seeing this wrong?
Hello Dr Matt. You have mentioned your rapa protocol is 12 weeks. Is that 12 weeks a year or do you resume after a break?
Hi Matt! One question regarding the difficulties in differentiating the "cancer supression" vs "biological age" effects of treatments in mouse. Wouldn't shifting to rat models in aging research be better since their end of life pathology exams show more "diverse" causes such as heart and kidney problems as well? For instance, would it be prohibitively expensive for the ITP to do tests in genetically heterogeneous rats instead? Interestingly, it seems that rapamycin does work on rats as well, further strengthening the idea that it is acting on the biology of aging itself.
But in the same genetic background the combination seems to work better. Mice are heterogenous and you cant think o f them like humans who are very similar to each other. So I would like to think there is something there. Also, I don't think you can superimpose data from two different genetic backgrounds and say that the life extinction obtained is similar. As Matt said the data does show that the combination works better.
Matt is the inverse of David Sinclair. And he sticks to an intellectual approach (unlike Rhonda P and Layme N).
Thanks Matt. Question; if it is really possible to measure a meaningful "biological age" just via DNA Methylation, would that not mean in return that most of the causes of aging truly are also in the epigenetics, like David Sinclair proposes?
Found this episode to be very informative, thanks for providing the insight.
Do we know the average lifespan of those humans that have the mutation in IL-11 signalling? Is there an effect?
Thanks Matt, incredibly useful for the layperson. We need more of this type of information out there.
Thank you for your insights! I know you've talked about level 2 and 3 longevity interventions (Taurine, etc…) and you are not taking any other longevity supplements besides Vitamin D and rapamycin… But can you please talk about the supplements of Novos Labs since they point to you as one of their consultants.
Second question. I did a dexa scan after watching one of your video's and it seems I have ostopenia. My doctor said that I could eat some more calcium rich foods but since I'm male that I shouldn't worry. So I've decided to try out calcium-akg… What do you think of that?
Unfortunate that you did not mention the impressive effect of reduced interleukin 11 around a variety of fibrotic diseases. Unfortunately the focus is entirely on lifespan where healthspan considerations may be just as important. For folks with a variety of chronic inflammatory conditions that result in fibrotic lesions, blocking interleukin 11 looks very promising