Gene Switch Stops Brain Plaques

In this short, new evidence is emerging that turning off heparan sulfate genes can decrease brain amyloid plaque formation, a key neuropathological component to Alzheimer’s disease. This new evidence has now been shown in transgenic mouse models where the heparan sulfate genes have been genetically engineered to turn off. This amazing evidence further confirms Dr Alan Snow’s 30-year old hypothesis that heparan sulfate proteoglycans are key to Alzheimer’s disease and its observed neuropathology (i.e. directly causing brain plaques, tangles and inflammation) as first hypothesized in 1989.

In the world premier of Doctor Snow’s Journal Club (Episode 1 -Part 1 and Part 2), we review and discuss the 2021 breakthrough paper in “Frontiers in Aging Neuroscience” by Snow et al entitled “The Unifying Hypothesis of Alzheimer’s Disease: Heparan Sulfate Proteoglycans are Key as First Hypothesized Over 30 Years Ago”. This paper was written by world-renowned PhD Neuropathologist, Inventor and Entrepreneur himself, Dr Alan Snow the host of “Doctor Snow’s Journal Club” and “The Doctor Snow Brain Health Show”. It discusses the real cause of Alzheimer’s disease that pertains brain aging with alterations to heparan sulfate proteoglycans that initiate the whole Alzheimer’s disease pathological process leading to the accumulation of plaques, tangles and inflammation -the trilogy of memory loss and the real reason we lose memory as we age.

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One of the world most renowned PhD Neuropathologists, Inventors (over 350+ issued patents) and Entrepreneurs (founded 2 different biotech companies), Dr Alan Snow, teaches all about his 30+ years of brain health research. 14 years as a Research Associate Professor at University of Washington Department of Pathology and project leader at the University of Washington Alzheimer’s Disease Research Center. Founded two different private biotechnology companies to develop new small molecule drugs (Company #1) and nutraceuticals (Company #2) for memory loss and brain aging, as well as neurodegenerative diseases and misfolded protein disorders.

In his career, Dr Snow has been granted 18 National Institute of Health (NIH) awards, a $3.5M LEAPS (Linked Efforts to Accelerate Parkinson’s Solutions) from the Michael J. Fox Foundation for Parkinson’s Disease Research, and is an inventor on 350+ issued patents in the USA and throughout the world for drugs, nutraceuticals and screening technologies for brain aging, memory loss, neurodegenerative diseases and misfolded protein disorders. In the late 1980’s/early 1990’s Dr Snow published papers with Dr Stanley Prusiner (who invented prion diseases and studies mad cow disease) who went on to win the Nobel Prize in Medicine in 1997.

In 2019, Dr Snow published a 109-page paper in Nature-Scientific Reports about the discovery of a plant from the Amazon rain forest whose polyphenols can enter the brain in minutes and start targeting brain plaques, tangles and inflammation, while markedly improving memory. This 2019 paper won the award for “The Top 100 Most Downloaded Research Papers for a nature journal in 2019”.

In 2021, Dr Snow produced a novel dietary supplement for memory support called Percepta and demonstrated it outperformed the top 20 memory-support dietary supplements in the marketplace by greater than 50% in reducing brain plaques and tangles as demonstrated by comparative testing and in vitro screening. The Percepta product consisting of exclusive and patented PTI-00703 cat’s claw (a concentrated form of cat’s claw) and oolong tea extract is backed by 34 patents (including composition of matter patents issued in 2019 and 2021). Dr Snow’s brain health channel is premiered by a new brain talk show called “The Doctor Snow Brain Health Show” hosted by Scott Alford (a brain enthusiast) and weekly covers different topics about brain health, brain aging and brain disease that Dr Snow spent most of his life exploring. In particular, Dr Snow tells stories of how he had to deal with how own mother having Alzheimer’s disease for 8 years before she died. This channel is the #1 channel on the internet for brain health, and brain secrets never revealed before.

Dr Snow’s brain research was secret for over 30 years and now in his mid 50’s decided to start a YouTube channel studying the brain since he was 20 years old. With over 659,000 subscribers, this is the fastest growing brain health channel on YouTube!

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