Cholesterol & Heart Health: Insights from LDL Research on Keto with Dave Feldman & Nick Norwitz, PhD
In this interview, Dave Feldman, citizen scientist and founder of the Citizen Science Foundation, and Nick Norwitz, Oxford PhD and Harvard medical student, discuss their latest study, which challenges the traditional view of LDL cholesterol and its relationship to heart disease risk and metabolic health. Their research focuses on lean mass hyper-responders (LMHRs)—lean, metabolically healthy individuals on a low-carb, high-fat diet, also known as a ketogenic diet. Their findings suggest that LDL cholesterol levels may not contribute to plaque buildup in these individuals as is commonly believed in the general population.
They also delve into the role of coronary CT angiograms as a powerful tool for more accurately diagnosing heart health and evaluating cardiovascular risk. This study provides new insights into the intersection of cholesterol, heart disease, and metabolic health, offering fresh perspectives on how we should rethink diet, cholesterol management, and long-term health outcomes.
Watch as they break down the intersection of cholesterol levels, heart disease, and metabolic health, offering fresh perspectives on assessing cardiovascular risk in modern medicine and calling for further research.
Don’t miss this enlightening discussion that could change how we view diet, cholesterol, and long-term health outcomes!
*Featured In This Video*
Dave Feldman
X: @realDaveFeldman
LinkedIn:
Nick Norwitz, PhD
X: @nicknorwitz
*Related Papers*
_Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a “Lean Mass Hyper-Responder” Phenotype_
_Carbohydrate Restriction-Induced Elevations in LDL-Cholesterol and Atherosclerosis: The KETO Trial_
_Carbohydrate restriction-induced elevations in LDL-cholesterol and atherosclerosis: The KETO Trial_
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Timestamps
0:00 Introduction
1:57 Overview of the Study on Lean Mass Hyper-Responders, Plaque, and LDL
2:39 Key Findings: Differences in Plaque Formation
4:48 The Lipid Hypothesis: Rethinking LDL’s Role in Heart Health
7:24 Is a Five-Year Study Enough to Draw Conclusions on LDL?
10:42 Does This Study Disprove LDL’s Link to Heart Disease?
12:39 How the Study’s Findings Are Changing Clinical Care
14:22 The Role of CT Angiograms in Understanding Heart Health
18:24 Insights on HDL, Triglycerides, and BMI from the Study
23:28 What’s Next for LDL, LMHR, and Heart Disease Research?
29:41 Challenging Mainstream Views with Innovative Research
38:02 Clinical Applications of LDL and Plaque Data
42:13 Conclusion
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