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Recent research reveals that up to 22% of patients with primary Sjogren’s Disease also develop monoclonal gammopathy of undetermined significance (M-GUS), likely due to chronic immune activation that overstimulates plasma cells and leads to abnormal M-protein production. This connection means patients with both conditions often face a more aggressive disease course, with increased risks of severe symptoms like parotid gland swelling, vasculitis, neurological complications, and cryoglobulinemia
Chapters:
00:00 Introductio n
00:33 What Is the Link Between MGUS and Sjogren’s?
01:19 Clinical Implications of MGUS in Sjogren’s Patients
02:12 How the Immune System Connects the Two
03:01 Why This Connection Matters
03:34 Should MGUS Be Monitored?
04:32 What Is a Myeloma Specialist?
05:32 Should MGUS Patients Get Genetic Testing?
06:31 Should MGUS Be Treated?
08:01 Final Takeaway
⚠️ Disclaimer: This video and its content are for general informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment.
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