🧬 New research from Weill Cornell Medicine reveals a concerning link between linoleic acid—a common omega-6 fatty acid found in seed oils like soybean and safflower oil, as well as in animal products like pork and eggs—and aggressive triple-negative breast cancer (TNBC).
The study, published in Science (March 14), suggests that high intake of linoleic acid can activate a growth pathway in tumor cells by binding to a protein called FABP5, which is especially abundant in triple-negative breast cancer cells. This subtype of cancer is known for being invasive, fast-spreading, and harder to treat, with a survival rate of 77% compared to 90% in hormone-sensitive subtypes.
In a mouse model, a diet high in linoleic acid led to enhanced tumor growth. Experts are urging caution around excessive consumption of vegetable and seed oils due to their potential inflammatory effects and cancer-promoting activity.
Dr. John Blenis, senior author of the study, emphasized the importance of this discovery in guiding personalized nutrition strategies for cancer prevention and treatment.
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